عرض تفاصيل البحث

ادناه جميع التفاصيل الخاصة بالبحث المطلوب عرضه. توفر هذه المنصة معلومات اساسية حول البحث, لمزيد من التفاصيل يرجى متابعة التصفح من خلال الضغط على الرابط الاصلي للبحث او رابط DOI.

عنوان البحث
Warfarin And Bisphosphontes Interaction In Patients Undergoing Total Knee Arthroplasty
عنوان المجلة
Journal Of Orthopaedics
ISSN-2589-9082
تفاصيل النشر
سنة النشر - 2024 / الفهرس الاصلي للمجلة - 49 : 0 (عدد الصفحات 5)
تصنيف البحث
العظام والكسور - المجموعة الطبية
رابط DOI
https://doi.org/10.1016/j.jor.2023.11.059
رابط البحث
فتح في موقع المجلة الرسمي
البحث والاستدامة
غير مرتبط باهداف التنمية المستدامة  
البحث والمجتمع
نعم , يدعم
الكلمات المفتاحية
knee arthroplasty, Warfarin , bisphosphontes

اسم الباحثجهة الانتساببلد الباحث
Ali Abdul Hussein Alshwilly University of Sumer Iraq
Hatim Abdul Kareem Alshwilly University of Sumer Iraq
Hanaa Hasan Kadhim University of Sumer Iraq

Background: Patients undergoing knee arthroplasty (TKA) surgery need anticoagulant therapy, mainly warfarin for prevention of venous thromboembolism (VTE). Warfarin is mainly eliminated by renal glomerular filtration where 92 % of warfarin is excreted in urine. Warfarin overdose may lead to significant bleeding and warfarin underdosing may cause VTE and other complications. Thus, international normalized ratio (INR) monitoring is crucial in TKA patients taking warfarin. Great interest has been expressed in bisphosphonate to reduce periprosthetic osteoporosis in patients undergoing total joint arthroplasty. Many human case reports and cohort studies proved bisphosphonates induced impaired renal function. Objectives: The main goal of the current study is to examine the pharmacodynamin effect of bisphosphonates on warfarin excretion and clinical effects in patients undergoing TKA surgery. Methods: Fifty patients undergoing TKA were recruited in the current study. Twenty five patients were given warfarin and twenty five patients were given warfarin and bisphosphonates starting three days after surgery. INR, major bleeding events and minor bleeding events were followed up in all recruited patients for one month after surgery. Results: warfarin plus zoledronic acid group had significantly higher percent of post INR greater than 4 (p = 0.022) and significantly higher percent of minor bleeding events (p = 0.041) than warfarin only group. Conclusion: Concomitant administration of bisphosphonates may increase warfarin bleeding adverse effects in elderly patient undergoing TKA.
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